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Updated: Feb 16, 2026
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Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
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Emerging concepts and recent advances in basal cell carcinoma
Mariam Totonchy1, David Leffell2
1Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208059, New Haven, CT 06520-8059, Connecticut, USA.
F1000Research
|December 21, 2017
Summary
Basal cell carcinoma (BCC) is a common skin cancer. This review covers surgical and emerging non-surgical treatments, including targeted therapies for advanced BCC.
Area of Science:
- Dermatology
- Oncology
Background:
- Basal cell carcinoma (BCC) is the most prevalent malignancy globally.
- BCC incidence is rising, increasing management challenges and treatment-related morbidity.
Purpose of the Study:
- To review current surgical and non-surgical treatment modalities for BCC.
- To highlight targeted molecular therapies for advanced or recurrent BCC.
Main Methods:
- Literature review of surgical interventions (Mohs micrographic surgery, excision).
- Review of non-surgical treatments, including approved targeted molecular therapies.
Main Results:
- Surgical interventions remain the standard of care with high cure rates.
- Non-surgical options, particularly targeted therapies, are expanding for advanced BCC.
Conclusions:
- Treatment strategies for BCC are evolving beyond traditional surgery.
- Targeted therapies offer new options for managing locally advanced or recurrent BCC.
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