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Profile of extrahepatic portal venous obstruction among children in Central India

Mayank Jain1, Jenisha Jain2, Gauri Rao Passi2

  • 1Global Health City, India.

Clinical and Experimental Hepatology
|December 21, 2017
PubMed

Insights

Home delivery and umbilical sepsis are significant risk factors for extrahepatic portal venous obstruction (EHPVO) in children. Most pediatric EHPVO patients present with gastrointestinal bleeding and respond well to endoscopic therapy or shunt surgery.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Vascular Surgery

Background:

  • Limited data exists on the clinical characteristics of pediatric extrahepatic portal venous obstruction (EHPVO) in Central India.
  • This study addresses the data gap by analyzing EHPVO cases in children from this region.

Purpose of the Study:

  • To investigate the clinical profile, risk factors, and treatment outcomes of pediatric EHPVO in Central India.
  • To identify potential associations between delivery practices and EHPVO development.

Main Methods:

  • Retrospective analysis of 30 pediatric patients diagnosed with EHPVO between 2002 and 2012.
  • Data collected included patient demographics, clinical presentation, risk factors, and treatment modalities.

Main Results:

  • The median age of presentation was 12.5 years, with a median symptom duration of 3.2 years.
  • Home delivery (100%) and umbilical sepsis (27%) were common, with some cases reporting traditional umbilical cord care.
  • Upper gastrointestinal bleeding (73.4%) and hypersplenism/pancytopenia (60%) were the primary presenting complaints.
  • Most patients required multiple endoscopic therapy sessions for varices, but funding issues led to high dropout rates (63.4%).
  • Seven patients underwent shunt surgery.

Conclusions:

  • Home delivery and umbilical sepsis are identified as significant risk factors for pediatric EHPVO.
  • Pediatric EHPVO commonly manifests as gastrointestinal bleeding and shows positive outcomes with endoscopic treatment and shunt surgery.
Abstract

Keywords:
oesophageal varicesportal hypertensionportal vein thrombosis

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