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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Bilateral uveitis following intravenous immunoglobulin administration
Enis D Kocak1, Bob Z Wang1, Anthony J Hall1
1Department of Ophthalmology, The Alfred Hospital, 55 Commercial Road, Melbourne, Victoria, Australia.
Intravenous immunoglobulin (IVIG) can cause acute anterior uveitis, an inflammatory eye condition. Promptly stopping IVIG and using corticosteroids resolved the uveitis in a patient, highlighting the importance of recognizing this adverse effect.
Area of Science:
- Ophthalmology
- Immunology
- Neurology
Background:
- Intravenous immunoglobulin (IVIG) is a therapy used for various autoimmune and neurological conditions.
- Adverse effects of IVIG can occur, necessitating careful monitoring of patients.
Observation:
- A 44-year-old female developed bilateral acute anterior uveitis within two days of starting IVIG for neuropathic pain.
- Ocular examination confirmed bilateral uveitis, prompting cessation of IVIG treatment.
Findings:
- Investigations for autoimmune and infectious etiologies of the uveitis were negative.
- The patient's uveitis resolved completely with topical corticosteroid treatment and discontinuation of IVIG.
Implications:
- Clinicians should consider uveitis as a potential adverse reaction to IVIG therapy.
- Early recognition and cessation of IVIG, coupled with appropriate treatment, can lead to favorable visual outcomes in cases of IVIG-induced uveitis.
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