Related Experiment Video
Updated: Feb 16, 2026
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
Published on: March 8, 2018
Neovascularization of the iris in retinoschisis
Geraldine R Slean1, Arthur D Fu1,2, Judy Chen1,2
1Department of Ophthalmology, California Pacific Medical Center, 711 Van Ness, Suite 250, San Francisco, CA, 94102, USA.
Purpose:
To report the association of rubeosis iridis with chronic bullous degenerative peripheral retinoschisis.
Observations:
A 63-year-old female presented with acute hyphema and neovascularization of the iris in association with elevated intraocular pressure. Posterior segment examination including imaging revealed no vascular occlusion as a potential cause. However, large, peripheral bullous retinoschisis was noted in the right eye. No nonperfusion aside from that seen within the schism detachment, or neovascularization of the retina on wide-field fundus photography or fluorescein angiography was noted. Bullous retinoschisis was also found in the left eye. The patient was treated conservatively with prednisolone acetate and timolol eye drops.
Conclusions And Importance:
Chronic bullous retinoschisis can be associated with anterior segment neovascularization such as rubeosis iridis, presumably due to non-perfusion within the retinoschisis cavity.
