Invasive papillary breast carcinoma, solid variant with neuroendocrine differentiation

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Invasive papillary carcinoma, solid variant is a rare breast malignancy.
• This tumor type typically affects elderly patients and generally has a favorable prognosis.

Purpose of the Study:

• To report a case of invasive papillary carcinoma, solid variant with neuroendocrine differentiation.
• To highlight the diagnostic and management process for this rare breast tumor.

Main Methods:

• Clinical presentation of a 72-year-old female patient with a left breast mass.
• Diagnostic workup including physical examination, mammography, and ultrasonography.
• Surgical management with modified radical mastectomy.
• Macroscopic tumor analysis.
• Histopathological and immunohistochemical analysis for definitive diagnosis.

Main Results:

• A 7 cm, well-limited, necrotic, and bleeding tumor was found in the left breast.
• The tumor occupied a significant portion of the breast area.
• Histopathological and immunohistochemical analyses confirmed invasive papillary carcinoma, solid variant with neuroendocrine differentiation.

Conclusions:

• Invasive papillary carcinoma, solid variant with neuroendocrine differentiation is a rare entity.
• Early diagnosis and surgical intervention are crucial for managing such breast tumors.
• This case contributes to the limited literature on this specific breast cancer subtype.