Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Gut-Protective TRPV1-Neuroepithelial Axis: Electroacupuncture Reverses Intestinal Damage in Diet-Induced Obesity.

Diabetes, obesity & metabolism·2026

Same author

Dnmt1 associated <i>Gja1</i> promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury.

Epigenetics·2026

Same author

An appropriate ASMI cutoff value enhances utilization of the CHARLS database for studying sarcopenia.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026

Same author

Differential associations between novel triglyceride-glucose-obesity indices and incident stroke in individuals with early-stage cardiovascular-kidney-metabolic syndrome: a longitudinal cohort study.

Cardiovascular diabetology·2026

Same author

A causal role of the ventromedial prefrontal cortex in regulating anticipated regret and risk behaviors in trait anxiety.

Psychological medicine·2026

Same author

Characteristics of Gut Microbiota in Patients with Chronic Obstructive Pulmonary Disease Based on Metagenomics and Metabolomics.

International journal of molecular sciences·2026

Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026

Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026

Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026

Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026

Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026

Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 16, 2026

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Published on: November 28, 2017

Electrochemical biosensor for cancer cell detection based on a surface 3D micro-array.

Li An¹, Guangtong Wang, Yu Han

¹State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. shaoqinliu@hit.edu.cn wgt@hit.edu.cn.

|December 21, 2017

Summary

This summary is machine-generated.

This study presents a novel method for capturing rare circulating tumour cells (CTCs) using a 3D microarray. The technique enhances CTC detection and allows for cell recovery, aiding early cancer diagnosis and treatment monitoring.

More Related Videos

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Published on: March 12, 2018

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

Related Experiment Videos

Last Updated: Feb 16, 2026

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Published on: November 28, 2017

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer

Published on: March 12, 2018

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

Area of Science:

Biomedical Engineering
Oncology
Nanotechnology

Background:

Circulating tumour cells (CTCs) are vital biomarkers for cancer diagnosis, therapy, and monitoring.
Current methods for CTC detection face challenges in efficiency and cell viability.

Purpose of the Study:

To develop an efficient and gentle strategy for capturing and detecting CTCs.
To improve early cancer diagnosis and real-time therapeutic monitoring.

Main Methods:

Utilized a benzoboric acid modified gold-plated polymeric substrate with a 3D surface array.
Engineered a reversible binding mechanism targeting sialic acid on CTCs.
Compared capture efficiency and cell recovery with smooth substrates.

Main Results:

The 3D microarray substrate demonstrated 3.8 times higher CTC capture efficiency than smooth substrates.
The benzoboric acid modification enabled easy and non-damaging detachment of captured CTCs.
Achieved high sensitivity, low cost, and recovery of isolated CTCs.

Conclusions:

The developed strategy offers enhanced CTC capture efficiency and high sensitivity.
The ability to recover intact CTCs facilitates downstream characterization.
This platform shows promise for early-stage cancer diagnosis and personalized therapy.