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Diabetic Retinopathy and Macular Edema Quality-of-Life Item Banks: Development and Initial Evaluation Using
Eva K Fenwick1,2,3, Jyoti Khadka4, Konrad Pesudovs4
1Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia.
Investigative Ophthalmology & Visual Science
|December 21, 2017
Summary
This study developed eight robust quality-of-life item banks for diabetic retinopathy (DR) and diabetic macular edema (DME). Computerized adaptive testing (CAT) using these banks efficiently measures treatment impact on patients.
Area of Science:
- Ophthalmology
- Psychometrics
- Health Outcomes Research
Background:
- Diabetic retinopathy (DR) and diabetic macular edema (DME) significantly impact patient quality of life (QoL).
- Accurate assessment of QoL is crucial for evaluating treatment effectiveness.
- Existing QoL measures may require refinement for optimal use in clinical trials and practice.
Purpose of the Study:
- To assess the psychometric properties of DR/DME quality-of-life (QoL) item banks.
- To determine the utility of calibrated item banks using computerized adaptive testing (CAT) simulations.
- To develop efficient and reliable QoL measures for DR/DME patients.
Main Methods:
- A cross-sectional study involving 514 participants with DR/DME.
- Rasch analysis was used to evaluate psychometric properties of 314 items across nine QoL domains.
- CAT simulations were performed on the resulting item banks.
Main Results:
- Eight operational QoL item banks were developed after refining initial pools and creating new ones (Driving, Lighting).
- Minor amendments were needed for Visual Symptoms, Mobility, Emotional, and Health Concerns item pools.
- CAT simulations demonstrated high correlations (0.88-0.99) with full banks, requiring only 3.6 and 7.2 items for moderate and high precision, respectively.
Conclusions:
- Eight psychometrically robust and efficient DR/DME item banks were successfully created.
- These item banks enable accurate assessment of QoL impact and treatment effectiveness.
- The developed banks facilitate precise QoL measurement with minimal patient burden via CAT.
