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[Functional diagnostics in endocrinology].

C J Auernhammer1, M Reincke2

  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland. christoph.auernhammer@med.uni-muenchen.de.

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Summary
This summary is machine-generated.

Functional diagnostic tests are crucial for diagnosing endocrinological diseases when basal lab results are inconclusive. This review covers key stimulation and suppression tests for various hormone disorders, aiding accurate diagnosis.

Keywords:
Adrenocortical insufficiencyAdrenocorticotropic hormoneCushing’s syndromeHyperaldosteronism, primaryPheochromocytoma

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Area of Science:

  • Endocrinology
  • Clinical Diagnostics

Background:

  • Basal laboratory parameters often insufficient for diagnosing endocrinological diseases.
  • Distinguishing physiological from pathological hormone secretion requires functional assessment.

Purpose of the Study:

  • To review essential functional diagnostic tests in endocrinology.
  • To discuss indications, principles, performance, reliability, and limitations of selected tests.

Main Methods:

  • Review of current guidelines and literature on endocrine functional tests.
  • Discussion of specific stimulation and suppression tests.

Main Results:

  • Covers tests for adrenal cortex insufficiency (ACTH stimulation test), Cushing's syndrome (dexamethasone inhibition test), primary hyperaldosteronism, pheochromocytoma, acromegaly, growth hormone deficiency, thyroid disorders, insulinoma, and Zollinger-Ellison syndrome.
  • Highlights tests recommended and explicitly not recommended in current practice.

Conclusions:

  • Functional tests are indispensable for accurate diagnosis of endocrine disorders.
  • Understanding test performance and limitations is vital for appropriate clinical application.