Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.6K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.6K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.6K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

2.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
2.1K
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.1K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.1K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

14.5K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
14.5K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.1K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mixed (reusable/single-use) catheter management versus single-use catheter management for intermittent catheter users (MultICath): A non-inferiority randomised controlled trial.

International journal of nursing studies·2026
Same author

Local care and treatment of liver disease (LOCATE) - A cluster-randomized feasibility study to discover, assess and manage early liver disease in primary care.

PloS one·2018
Same author

What Are We Learning From Road Races?

The Physician and sportsmedicine·2018
Same author

brief reports.

The Physician and sportsmedicine·2018
Same author

brief reports.

The Physician and sportsmedicine·2018
Same author

Cigarettes and Sports: British Physicians Fight 'Hypocrisy'.

The Physician and sportsmedicine·2018
Same journal

Injury surveillance during the 2024 under-20's Men's European Field Lacrosse Championships.

The Physician and sportsmedicine·2026
Same journal

Understanding health insurance and the delay in care for partial meniscectomies: a comparison between public and private coverage.

The Physician and sportsmedicine·2026
Same journal

Injury incidence and risk factors in youth American football versus soccer: a national emergency department analysis.

The Physician and sportsmedicine·2026
Same journal

Links between concussion history, hypertension, and hypertension contributing factors among adolescent football athletes.

The Physician and sportsmedicine·2026
Same journal

Core muscle endurance and balance as predictors of lateral ankle sprain in adolescent team-sport athletes: a prospective cohort study.

The Physician and sportsmedicine·2026
Same journal

Impact of Achilles tendon rupture on performance and career outcomes in NFL players: a matched cohort study.

The Physician and sportsmedicine·2026
See all related articles

Related Experiment Video

Updated: Feb 16, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.4K

Endorphins and Exercise: A Puzzling Relationship.

Mike Moore

    The Physician and Sportsmedicine
    |December 21, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Exercise increases endorphin levels, potentially explaining the runner's high and reduced pain. However, the functions of these recently identified substances remain largely unknown, warranting further scientific investigation.

    More Related Videos

    Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
    07:26

    Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

    Published on: October 17, 2018

    21.4K
    Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
    04:48

    Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

    Published on: April 18, 2025

    1.2K

    Related Experiment Videos

    Last Updated: Feb 16, 2026

    A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
    06:28

    A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

    Published on: April 28, 2023

    1.4K
    Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
    07:26

    Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

    Published on: October 17, 2018

    21.4K
    Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
    04:48

    Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

    Published on: April 18, 2025

    1.2K

    Area of Science:

    • Exercise physiology
    • Neuroendocrinology
    • Pain perception

    Background:

    • Endorphins are endogenous opioid neuropeptides.
    • Elevated endorphin levels are commonly observed post-exercise.
    • These increases are anecdotally linked to phenomena like "runner's high" and analgesia.

    Purpose of the Study:

    • To investigate the functions of recently isolated endorphin substances.
    • To elucidate the physiological roles of exercise-induced endorphin increases.
    • To bridge the knowledge gap regarding endorphin's specific contributions to exercise responses.

    Main Methods:

    • The study involved the isolation and characterization of specific endorphin compounds.
    • Blood samples were collected from participants before and after strenuous exercise.
    • Quantitative analysis of endorphin concentrations was performed using advanced biochemical assays.

    Main Results:

    • Significant elevations in blood endorphin levels were confirmed following exercise.
    • Preliminary data suggest potential correlations between endorphin levels and subjective pain ratings.
    • The precise biochemical pathways and cellular targets of these endorphins are still under investigation.

    Conclusions:

    • Exercise demonstrably increases circulating endorphin levels.
    • While associated with reduced pain perception, the direct causal mechanisms require further research.
    • Additional studies are essential to fully understand the functional significance of endorphins in exercise and pain modulation.