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The Timecourse of Global Cognitive Gains from Supervised Computer-Assisted Cognitive Training: A Randomised,
1Michael Valenzuela, Regenerative Neuroscience Group, Brain and Mind Research Institute, 94 Mallett St Camperdown, Sydney NSW 2050, Australia, michael.valenzuela@sydney.edu.au, T +61 2 9114 4135 F +61 2 9351 0930.
The Journal of Prevention of Alzheimer'S Disease
|December 21, 2017
Summary
Supervised, group-based cognitive training significantly improved global cognition, memory, and processing speed in older adults. These cognitive enhancements were durable, persisting even after training concluded.
Area of Science:
- Gerontology
- Cognitive Neuroscience
- Clinical Psychology
Background:
- Home-based computerised cognitive training (CCT) has shown limited effectiveness in improving global cognition, a crucial indicator of cognitive aging.
- Older adults with dementia risk factors require effective interventions to maintain cognitive function.
Purpose of the Study:
- To evaluate the efficacy of supervised, group-based, multidomain CCT in enhancing global cognition among older adults.
- To investigate the dose-response relationship of CCT during and after the training period.
Main Methods:
- A randomized, double-blind, longitudinal, active-controlled trial involving 80 non-demented older adults (mean age 72.1) with dementia risk factors.
- Participants underwent 36 group-based sessions over three months, either CCT or active control (audiovisual educational exercises).
- Global cognition was assessed using a composite score of memory, speed, and executive function; activities of daily living were a secondary outcome.
Main Results:
- Significant improvements in global cognition were observed in the CCT group compared to the active control group, with effects increasing over 3 months and persisting for 3 months post-training.
- Durable enhancements were noted in memory and processing speed, with dose-response characteristics varying by cognitive domain.
- Training effects gradually diminished but residual gains were evident up to 12 months post-training; no significant effects on daily living activities or adverse events were reported.
Conclusions:
- Group-based CCT is a safe and effective intervention for older adults with dementia risk factors, significantly improving overall cognition, memory, and processing speed.
- Understanding the domain-specific dose-response relationships is crucial for optimizing CCT implementation in clinical and community settings and for future trial design.
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