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Published on: December 7, 2017
Hypothalamic GRP78, a new target against obesity?
Cristina Contreras1,2, Marcos F Fondevila1,2, Miguel López1,2
1a NeurObesity Group, Department of Physiology, CIMUS , University of Santiago de Compostela, -Instituto de Investigación Sanitaria , Santiago de Compostela , Spain.
Abstract:
The chaperone GRP78 (glucose related protein 78), also called BiP (binding immunoglobulin protein) is a key regulator of endoplasmic reticulum (ER) stress. We recently described that over-expression of GRP78 specifically in the ventromedial nucleus of the hypothalamus (VMH) releases hypothalamic ER stress in rodent obese models leading to weight loss, reduced hepatic steatosis and improved insulin and leptin sensitivity. The action of GRP78 is mediated by a feeding-independent mechanism involving increased sympathetic tone, augmented brown adipose tissue (BAT) thermogenesis and induction browning of white adipose tissue (WAT).
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