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Microglial Activation on 11C-CB184 PET in a Patient With Cerebellar Ataxia Associated With HIV Infection
Abstract:
A 63-year-old man complaining of prolonged imbalance underwent C-CB184 PET to assess microglial activation 3 years after being diagnosed with cerebellar ataxia associated with HIV infection. C-CB184 images revealed significant cerebellar uptake where MRI signal abnormalities were observed at disease onset, although these abnormalities had mostly disappeared at the time of C-CB184 PET. Microglia are believed to be a long-term reservoir for HIV infection, causing persistent immune activation (ie, chronic inflammation). Hence, in this case, increased C-CB184 binding may reflect persistent microglial activation along with HIV persistence in the cerebellum. However, further pathological investigations are desired to validate C-CB184 PET.
Insights
Positron emission tomography with C-CB184 revealed persistent microglial activation in the cerebellum of an HIV-associated cerebellar ataxia patient, suggesting ongoing inflammation and potential HIV persistence.
Area of Science:
- Neuroimmunology
- Infectious Diseases
- Radiology
Background:
- HIV infection can lead to cerebellar ataxia, characterized by persistent immune activation and inflammation.
- Microglia, the brain's immune cells, may serve as reservoirs for HIV, contributing to chronic inflammation.
- Cerebellar ataxia symptoms, like imbalance, can persist long after initial diagnosis.
