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18F-FDG PET/CT and MRI in Necrotizing Autoimmune Myopathy: "The Scarface Sign"

Coralie Pelissou, Nathalie Lerolle, Céline Labeyrie

    Clinical Nuclear Medicine
    |December 21, 2017
    PubMed

    Insights

    Necrotizing autoimmune myopathy (NAM) is a rare muscle disease characterized by cell death without significant inflammation. This case highlights NAM

    Area of Science:

    • Neurology
    • Immunology
    • Oncology

    Background:

    • Necrotizing autoimmune myopathy (NAM) is an idiopathic inflammatory myopathy subgroup.
    • Characterized by myocyte necrosis with minimal inflammation.
    • Can be idiopathic or associated with various conditions like malignancy or viral infections.

    Observation:

    • A 58-year-old man presented with suspected paraneoplastic syndrome.
    • The patient had a diagnosis of NAM.
    • Referred for PET imaging to investigate potential malignancy.

    Findings:

    • PET/CT revealed abnormalities requiring further investigation.
    • Contrast-enhanced CT and 3D T1-weighted MRI were used to clarify PET/CT findings.
    • Imaging aimed to resolve abnormalities in the context of NAM and suspected paraneoplastic syndrome.

    Implications:

    • This case underscores the importance of comprehensive imaging in diagnosing paraneoplastic syndromes associated with NAM.
    • Highlights the role of advanced imaging techniques like PET/CT and MRI in evaluating complex cases.
    • Contributes to understanding the diagnostic challenges and approaches in necrotizing autoimmune myopathy.

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