Cytogenetic studies in an acute leukemia patient following cerebellar astrocytoma

Acute, monomyelogenous leukemia (AMML) was diagnosed in a patient with a derived 13;14 translocation and prior treatment for a cerebellar astrocytoma. A bone marrow aspirate at the time of diagnosis of leukemia showed abnormalities of chromosome 11, 12 and 16 in addition to the constitutional aberration. The patient's mother carried the same 13;14 translocation, as did 2 siblings, a maternal uncle, and four of his six children. The father had a reciprocal translocation between numbers 1 and 19 which was incidental to the present study.