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Characterization of KPC-Encoding Plasmids from Enterobacteriaceae Isolated in a Czech Hospital

Rudolf Kukla¹, Katerina Chudejova^2,3, Costas C Papagiannitsis^4,2,3

¹Department of Clinical Microbiology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Antimicrobial Agents and Chemotherapy

|December 22, 2017

Abstract:

Ten Enterobacteriaceae isolates collected in a Czech hospital carried bla_KPC-positive plasmids of different sizes (∼30, ∼45, and ∼80 kb). Sequencing revealed three types of plasmids (A to C) with the Tn4401a transposon. Type A plasmids comprised an IncR backbone and a KPC-2-encoding multidrug resistance (MDR) region. Type B plasmids were derivatives of type A plasmids carrying an IncN3-like segment, while type C plasmids were IncP6 plasmids sharing the same KPC-2-encoding MDR region with type A and B plasmids.

Keywords:

Citrobacter freundii Illumina sequencing IncR ST18 Tn4401a

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