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Related Experiment Video

Updated: Feb 16, 2026

Assessment of Social Cognition in Non-human Primates Using a Network of Computerized Automated Learning Device ALDM Test Systems

Assessment of Social Cognition in Non-human Primates Using a Network of Computerized Automated Learning Device ALDM Test Systems

Published on: May 5, 2015

Attention Shifts Recruit the Monkey Default Mode Network.

John T Arsenault^1,2, Natalie Caspari^1,3, Rik Vandenberghe^4,3

¹Laboratory for Neuro- and Psychophysiology, Neurosciences Department, KU Leuven Medical School, 3000 Leuven, Belgium.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|December 22, 2017

Summary

This summary is machine-generated.

Cognitive shifting, or changing attention, activates the default mode network (DMN) in primates, suggesting this brain network

Keywords:

DMN attention cognition fMRI monkey

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Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

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Published on: August 1, 2018

Area of Science:

Neuroscience
Cognitive Neuroscience
Primate Cognition

Background:

The default mode network (DMN) is active during rest and internally focused tasks, but its unifying function remains unclear.
While DMN activity is observed in humans and other species, its role in evolutionarily preserved cognitive functions is debated.
Previous studies suggest cognitive shifts in humans recruit the DMN, but this remains unconfirmed in nonhuman primates.

Purpose of the Study:

To investigate whether significant changes in cognitive context recruit DMN regions in nonhuman primates.
To determine if cognitive shifting, specifically spatial attention shifts, activates the DMN in macaques.
To explore the evolutionary conserved functions of the DMN.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used in macaques to measure brain activity during a demanding attention task.
Researchers compared brain activity during spatial shifts of attention (cognitive shifts) versus maintaining attention (stay events).
Resting-state fMRI data were used for functional clustering to compare DMN regions with task-activated regions.

Main Results:

A cortical network activated during cognitive shifts largely overlapped with the DMN in macaques.
fMRI data showed significant shift selectivity in DMN regions during the attention task.
Functional clustering revealed that DMN and shift-selective regions grouped together, distinct from stay-event regions.

Conclusions:

Cognitive shifting in primates generally recruits DMN regions.
This finding suggests that cognitive flexibility may be an evolutionarily preserved function of the DMN.
Dysfunction in the DMN could underlie cognitive flexibility decline in neurological diseases.