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Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting

Jiahui Cao1, Manuel Ehling2, Sigrid März1

  • 1Institute of Anatomy and Vascular Biology, Westfälische Wilhelms University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

Nature Communications
|December 22, 2017
PubMed
Summary

Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) and Notch signaling promote angiogenesis by remodeling endothelial cell junctions. This study reveals how VEGF-induced cell elongation and junction-associated intermittent lamellipodia (JAIL) drive cell migration and vessel formation.

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