Related Experiment Video

Updated: Feb 16, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.9K

[Relationship between large artery elasticity function and coronary heart disease, lower extremity arterial disease

H Liu1, H Y Wang1, J B Liu1

  • 1Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|December 22, 2017
PubMed

Insights

In patients with carotid plaque, reduced large artery elasticity is linked to coronary heart disease (CHD) or lower extremity arterial disease (LEAD) in those under 61.66 years. Arterial stiffness is a significant risk factor for these conditions in younger individuals.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Arterial Physiology

Background:

  • Carotid plaque is a marker for systemic atherosclerosis.
  • Large artery elasticity, assessed by carotid-femoral pulse wave velocity (CF-PWV), is crucial for cardiovascular health.
  • Coronary heart disease (CHD) and lower extremity arterial disease (LEAD) are significant causes of morbidity and mortality.

Purpose of the Study:

  • To investigate the association between large artery elastic function and the presence of CHD or LEAD in patients with carotid plaque.
  • To determine if arterial stiffness is an independent risk factor for CHD/LEAD in this population.
  • To explore age-related differences in this association.

Main Methods:

  • A cohort of 491 patients with carotid plaque underwent arterial stiffness assessment (CF-PWV) and blood tests.
  • Patients were categorized into non-CHD&LEAD and CHD/LEAD groups.
  • Multivariate logistic regression analyzed the independent association between high arterial stiffness (CF-PWV > 9 m/s) and CHD/LEAD, stratified by age (mean age 61.66 years).

Main Results:

  • The study population exhibited high arterial stiffness (mean CF-PWV 10.71 m/s) and a high prevalence of arteriosclerosis (76.6%) and CHD/LEAD (36.9%).
  • Patients with CHD/LEAD had higher prevalence of risk factors including age, male sex, smoking, SBP, HbA1c, Hcy, Cr, and hypertension/diabetes.
  • Large artery stiffness (CF-PWV > 9 m/s) was an independent risk factor for CHD/LEAD in patients younger than 61.66 years (OR=3.229, P<0.05), but not in older patients.

Conclusions:

  • Patients with carotid plaque often have impaired large artery elasticity.
  • Higher large artery stiffness significantly increases the risk of CHD/LEAD in patients with carotid plaque who are younger than 61.66 years.
  • Independent risk factors for CHD/LEAD differ between younger and older patients with carotid plaque.
Abstract

More Related Videos

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.6K
A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

716

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
586
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
408
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
559
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
462
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.2K