Primary Cutaneous B-cell Lymphomas: Case Report of Two Cases

Area of Science:

• Dermatology
• Oncology
• Hematology

Background:

• Primary cutaneous lymphomas (PCLs) are rare lymphoproliferative disorders affecting the skin.
• B-cell lymphomas constitute 20%-25% of PCL cases, with primary cutaneous diffuse large B-cell lymphomas (PCDLBCLs) being aggressive and having a poor prognosis.
• Timely diagnosis is crucial for effective treatment of PCDLBCLs.

Purpose of the Study:

• To report two cases of PCDLBCL presenting as rapidly growing skin nodules.
• To highlight the diagnostic approach including clinical, histomorphological, and immunohistochemical features.
• To emphasize the efficacy of systemic chemotherapy in managing PCDLBCL.

Main Methods:

• Clinical presentation analysis of two patients with rapidly enlarging skin nodules.
• Histomorphological examination of skin lesions.
• Immunohistochemical analysis to confirm PCDLBCL diagnosis.
• Treatment with systemic anthracycline-based chemotherapy (R-CHOP).

Main Results:

• Both patients presented with rapidly enlarging skin nodules consistent with PCDLBCL.
• Diagnosis was confirmed through histomorphology and immunohistochemistry.
• Both patients achieved complete remission following R-CHOP chemotherapy.
• No evidence of relapse or extracutaneous dissemination was observed during a 6-month follow-up.

Conclusions:

• PCDLBCLs, though aggressive, can be effectively treated with systemic chemotherapy.
• Early and accurate diagnosis is key to successful management and improved patient outcomes.
• Systemic R-CHOP chemotherapy demonstrated significant efficacy in the reported cases.