Renal cell carcinoma: An update for the practicing urologist
Sumanta K Pal1, Paulo Bergerot2, Robert A Figlin3
1Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Asian Journal of Urology
|December 22, 2017
Summary
Systemic therapy for metastatic renal cell carcinoma (mRCC) is evolving, with ongoing trials exploring new treatments. Future studies will clarify the roles of adjuvant therapy and cytoreductive nephrectomy in mRCC management.
Area of Science:
- Oncology
- Nephrology
Background:
- Systemic therapy for metastatic renal cell carcinoma (mRCC) has advanced, with vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors as standard care.
- Clinical trials are crucial for refining mRCC treatment strategies.
Purpose of the Study:
- To review the current status of clinical trials in metastatic renal cell carcinoma.
- To examine ongoing and recently completed studies evaluating novel therapeutic approaches.
Main Methods:
- Review of recently completed and ongoing clinical trials in mRCC.
- Analysis of data regarding localized disease, cytoreductive nephrectomy, and first-line management.
Main Results:
- Observation is standard post-localized resection, but trials assessing VEGF- and mTOR-therapies are active.
- Retrospective data support cytoreductive nephrectomy with targeted agents, but prospective data are pending.
- First-line mRCC management may be significantly altered by ongoing trials of vaccines, immune checkpoint inhibitors, and novel targeted agents.
Conclusions:
- Prospective studies in the coming years are critical for defining the roles of adjuvant therapy and cytoreductive nephrectomy in mRCC.
- The current first-line treatment paradigm for mRCC is expected to evolve significantly.
Keywords:
CabozantinibCytoreductive nephrectomyImmunotherapyPD-1Renal cell carcinomaSdjuvant therapyVaccinesMore Related Videos
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