Related Experiment Video
Updated: Aug 4, 2026
08:14
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
13.5K
Autologous Platelet-rich Plasma after Third Molar Surgery
Adil Gandevivala1, Amit Sangle2, Dinesh Shah1
1Department of Oral and Maxillofacial Surgery, MGM Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Annals of Maxillofacial Surgery
|December 22, 2017
Summary
Autologous platelet-rich plasma (PRP) significantly improved wound healing and reduced periodontal pocket depth after third molar surgery. While PRP showed potential for reducing pain and swelling, these effects were not statistically significant in this study.
Area of Science:
- Oral Surgery
- Regenerative Medicine
- Periodontology
Background:
- Impacted third molars are common, often requiring surgical extraction.
- Postoperative complications like pain, swelling, and poor healing can impact patient recovery.
- Platelet-rich plasma (PRP) is a concentrate of growth factors with potential regenerative properties.
Purpose of the Study:
- To evaluate the efficacy of autologous platelet-rich plasma (PRP) in managing pain, swelling, healing, and periodontal status after impacted mandibular third molar surgery.
- To compare outcomes between patients receiving PRP and those undergoing standard surgical procedures.
Main Methods:
- A comparative study involving 25 patients undergoing bilateral impacted mandibular third molar extraction.
- Surgical sites were either closed primarily (control) or treated with PRP followed by primary closure (case group).
- Outcomes including pain, swelling, wound healing, and periodontal pocket depth were assessed over a 2-month follow-up period.
Main Results:
- PRP application significantly improved wound healing (p=0.001) and reduced periodontal pocket depth (p=0.001) compared to the control group.
- A trend towards reduced pain and facial swelling was observed in the PRP group by day 3, but these differences were not statistically significant.
- No significant difference in pain or swelling was noted between groups by day 3.
Conclusions:
- Autologous platelet-rich plasma (PRP) is effective in improving wound healing and reducing periodontal pocket depth following impacted third molar surgery.
- PRP may help lessen immediate postoperative sequelae, though further research is needed to confirm significant reductions in pain and swelling.
More Related Videos
Related Concept Videos
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:16Clot Retraction and Fibrinolysis
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.