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Adrenal Gland Disorders01:27

Adrenal Gland Disorders

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Major Hormones and Their Functions01:27

Major Hormones and Their Functions

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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
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Cranial Bones: Lateral View01:27

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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Central serous chorioretinopathy following intramuscular testosterone therapy in prolactinoma.

Oxford medical case reports·2026
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[<sup>68</sup>Ga]Ga-DOTATATE uptake in pheochromocytoma/paraganglioma predicts SSTR2 expression by immunohistochemistry: Strongest uptake in head and neck paraganglioma.

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Pachydermoperiostosis Masquerading as Acromegaly.

Munira M Karimova1, Zamira Yu Halimova1, Yulduz M Urmanova1

  • 1Department of Neuroendocrinology, Center of the Scientific and Clinical Study of Endocrinology, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan 100140.

Journal of the Endocrine Society
|December 22, 2017
PubMed
Summary

Pachydermoperiostosis, a rare genetic disorder, can mimic acromegaly symptoms. Genetic testing identified a homozygous mutation in SLCO2A1, confirming this important differential diagnosis.

Area of Science:

  • Genetics
  • Endocrinology
  • Dermatology

Background:

  • Acromegaly is typically diagnosed based on clinical presentation and confirmed biochemically.
  • Differential diagnoses are crucial for accurate patient management and therapy optimization.
Keywords:
acromegalydiagnosispachydermoperiostosispulmonary hypertrophic osteoarthropathy

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