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Acute ventilatory failure in multiple sclerosis.

T Yamamoto1, T Imai, M Yamasaki

  • 1Department of Neurology, Kitano Hospital, Osaka, Japan.

Journal of the Neurological Sciences
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Acute ventilatory failure in multiple sclerosis (MS) is rare but linked to brainstem lesions. Early recognition and ventilation offer a good chance of recovery for MS patients.

Area of Science:

  • Neurology
  • Pathology

Background:

  • Multiple sclerosis (MS) is typically not associated with acute ventilatory failure.
  • Few clinicopathological investigations exist for MS-related respiratory compromise.

Observation:

  • Four patients with MS presented with acute ventilatory failure and neurological signs suggesting midline ventral medullary lesions.
  • One patient died from anoxic encephalopathy a year later; two deceased cases showed medullary lesions and MS foci with necrotic changes.

Findings:

  • Midline ventral medullary lesions were identified in MS patients experiencing acute ventilatory failure.
  • Pathological findings in Japanese MS patients included necrotic changes in lesions, differing from Western MS.
  • MRI confirmed a caudal medullary lesion in one patient.

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Implications:

  • Acute ventilatory failure may be an underrecognized manifestation of MS, particularly in Japanese populations.
  • Early identification of this symptom complex is crucial for patient assessment and treatment.
  • Prompt artificial ventilation can lead to recovery in MS patients with acute ventilatory failure.