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Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow
Teresa Massam-Wu1, Stuart A Cain1, Cay M Kielty2
1Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Biology, Medicine and Health, University of Manchester, Manchester, UK.
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We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.

