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Updated: Feb 16, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data
Vijayachitra Modhukur1, Tatjana Iljasenko1, Tauno Metsalu1
1Institute of Computer Science, University of Tartu, 50409 Tartu, Estonia.
Aim:
To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & Methods:
We utilized methylome data from 'The Cancer Genome Atlas' and used the Cox proportional-hazards model to develop an interactive web interface for survival analysis.
Results:
MethSurv enables survival analysis for a CpG located in or around the proximity of a query gene. For further mining, cluster analysis for a query gene to associate methylation patterns with clinical characteristics and browsing of top biomarkers for each cancer type are provided. MethSurv includes 7358 methylomes from 25 different human cancers.
Conclusion:
The MethSurv tool is a valuable platform for the researchers without programming skills to perform the initial assessment of methylation-based cancer biomarkers.
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