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Fibronectin glomerulopathy - A sporadic case with unusual clinical manifestation
Surya Narayan Mandal1, Sumita Shrivastava2, Rossella Piras3
1Department of Nephrology, NH Malla Reddy Narayana Multispeciality Hospital, Telangana, Hyderabad, India.
Abstract:
A 22-year-old nondiabetic young Indian female presented with short history of dyspnea, anorexia, and bilateral leg swelling. Her laboratory evaluation showed severe anemia, serum creatinine of 11.89 mg/dL, nephrotic range proteinuria and microscopic hematuria with 6-8 red blood cell/high-power field. Renal biopsy showed brightly eosinophilic, periodic acid-Schiff (PAS) positive, silver negative, and fuschinophilic deposits in the mesangium extending around the capillary loops with thickening of the basement membrane. Immunohistochemistry was strongly positive for fibronectin (FN). There was no family history of renal disease. Genetic screening revealed absence of mutations in the FN1 gene. She was put on maintenance hemodialysis.
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