Related Experiment Video
Updated: Feb 16, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
Technical Note: Comparison of first- and second-generation photon-counting slit-scanning tomosynthesis systems
Karl Berggren1, Björn Cederström2, Mats Lundqvist2
1Physics of Medical Imaging, Royal Institute of Technology, AlbaNova University Center, Stockholm, 106 91, Sweden.
A new second-generation photon-counting slit-scanning digital breast tomosynthesis (DBT) system offers improved image quality and accessibility. This advanced DBT technology enhances breast-cancer screening by maintaining key features while improving modulation transfer function and detective quantum efficiency.
Area of Science:
- Medical Imaging
- Radiology
- Biomedical Engineering
Background:
- Digital breast tomosynthesis (DBT) is an advanced imaging technique for breast-cancer detection.
- Photon-counting detectors offer potential advantages in spectral information and noise reduction for DBT.
- Developing improved DBT systems is crucial for enhancing screening and diagnostic accuracy.
Purpose of the Study:
- To introduce a second-generation photon-counting slit-scanning DBT system.
- To compare the geometry and image quality of the second-generation system with its first-generation predecessor.
- To present initial image quality assessments of the novel second-generation system.
Main Methods:
- The second-generation system utilizes a novel geometry with combined rotational and linear motion.
- Updated calibration routines were implemented for enhanced performance.
- Image quality was evaluated using in-slice modulation transfer function (MTF), artifact spread function (ASF), and detective quantum efficiency (DQE) at the image center.
Main Results:
- The in-slice 50% MTF improved in the chest-mammilla direction from 3.2 to 3.5 lp/mm.
- The zero-frequency DQE increased from 0.71 to 0.77, indicating improved detection efficiency.
- The new system demonstrated reduced in-slice variation of the tomographic angle and increased maximum compression height.
Conclusions:
- The second-generation DBT system's new geometry reduces tomographic-angle variation and enhances patient accessibility.
- Improvements in MTF and DQE are attributed to updated calibration procedures.
- The second-generation system retains the benefits of photon-counting technology while improving image quality and patient accommodation.
Related Concept Videos
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography
Confocal Fluorescence Microscopy
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET

