Related Experiment Video
Updated: Feb 16, 2026
14:56
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
5.2K
Obesity genetics: insights from the Pakistani population.
M Pigeyre1,2, M Saqlain3, M Turcotte1
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
Summary
Pakistan
Area of Science:
- Genetics and Population Health
- Obesity Research
- Nutritional Transition
Background:
- Pakistani population exhibits significant genetic diversity due to historical admixture.
- Rapid nutritional transition in Pakistan is linked to a rising prevalence of obesity and associated health issues.
- Understanding genetic predispositions to obesity is crucial amidst environmental changes.
Purpose of the Study:
- To review the ancestral origins of the Pakistani population.
- To explore societal factors contributing to the obesity epidemic in Pakistan.
- To identify genetic factors, including syndromic, monogenic, and polygenic obesity genes, within the Pakistani population.
Main Methods:
- Review of existing literature on Pakistani population genetics and obesity.
- Analysis of societal determinants and governmental management strategies for obesity.
- Discussion of gene identification approaches, including studies on consanguineous families and gene × environment interactions.
Main Results:
- The review details the genetic admixture of the Pakistani population.
- Societal factors and governmental approaches to obesity are discussed.
- Contribution of various obesity genes (syndromic, monogenic, polygenic) in Pakistanis is described.
Conclusions:
- Elucidating the genetic basis of obesity in Pakistan offers insights into gene-environment interactions.
- This research can inform novel strategies for obesity prevention and treatment.
- Understanding genetic factors in diverse populations like Pakistan's is vital for global health advancements.
More Related Videos
13:09Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Published on: April 4, 2012
16.6K
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
3.0K
Related Concept Videos
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
301
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
301
01:24Obesity
1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
197
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
197
01:28Human Genetics
1.7K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.7K
01:21Drug Dosing: Obese Patients
275
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
275
01:29Pharmacogenomics: Identification of New Drug Targets
9
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
9