Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.2K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extending the age cutoff: Outcomes of the Ross procedure in patients older than 60 years. A two-center retrospective study from the Canadian Ross Registry.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Readiness to Consider and Adopt Genetic and Genomic Tests in Canada-An Update to the State of Readiness Report.

Current oncology (Toronto, Ont.)·2026
Same author

Interferon-Inducible Gene Upregulation Correlates With Successful Viral Clearance in Patients With BK Polyomavirus-Associated Nephropathy.

Kidney international reports·2026
Same author

Glucagon-Like Peptide-1 Receptor Agonists: Are We Swapping One Public Health Crisis for Another?

Australasian journal on ageing·2026
Same author

Corrigendum to "Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: A multicenter international study" [American Journal of Transplantation 25 (2025) 1631-1642].

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Clazakizumab in the treatment of chronic active antibody-mediated kidney transplant rejection: Results from the IMAGINE phase 3, randomized, double-blind, placebo-controlled study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
Same journal

Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps.

Artificial organs·2026
See all related articles

Related Experiment Video

Updated: Feb 16, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.6K

A Decrease in Hypoxic Pulmonary Vasoconstriction Correlates With Increased Inflammation During Extended Normothermic

Sayed Himmat1,2, Almothana Alzamil1,2, Nader Aboelnazar1,2

  • 1Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Artificial Organs
|December 22, 2017
PubMed
Summary
This summary is machine-generated.

Hypoxic pulmonary vasoconstriction (HPV) during normothermic ex vivo lung perfusion (EVLP) offers a sensitive measure of donor lung quality. HPV response blunting indicates subclinical lung deterioration, even with stable standard parameters.

Keywords:
-Hypoxic pulmonary vasoconstriction-Lung physiology-Pulmonary vascular resistanceEx vivo lung perfusion

More Related Videos

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
13:32

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices

Published on: January 14, 2014

11.4K
Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
09:34

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation

Published on: October 31, 2025

390

Related Experiment Videos

Last Updated: Feb 16, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.6K
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
13:32

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices

Published on: January 14, 2014

11.4K
Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
09:34

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation

Published on: October 31, 2025

390

Area of Science:

  • Transplantation immunology
  • Pulmonary medicine
  • Ex vivo organ perfusion

Background:

  • Normothermic ex vivo lung perfusion (EVLP) is a developing method for assessing donor lung viability.
  • Standard physiological parameters during EVLP may not fully capture subtle declines in lung function.

Purpose of the Study:

  • To investigate the utility of hypoxic pulmonary vasoconstriction (HPV) as a sensitive indicator of donor lung quality during EVLP.
  • To determine if HPV response during EVLP correlates with inflammatory markers and predicts subclinical lung function changes.

Main Methods:

  • Eight porcine lungs underwent 10-hour EVLP using autologous blood and STEEN solution.
  • Standard physiological parameters (compliance, peak airway pressure, PVR) and oxygenation (PO2/FiO2) were monitored.
  • HPV response was assessed by measuring changes in pulmonary vascular resistance (ΔPVR) under hypoxic conditions.
  • Cytokine levels (IL-6, TNF-α) were measured and correlated with HPV response.

Main Results:

  • Standard physiological parameters and oxygenation remained stable throughout the 10-hour EVLP.
  • A robust HPV response was observed for the first 4 hours, followed by a significant blunting after 6 hours (P < 0.01).
  • The decrease in HPV response showed an inverse correlation with elevated Interleukin-6 and tumor necrosis factor-α levels (P < 0.01).

Conclusions:

  • Subclinical deterioration of donor lung function can occur during EVLP despite stable standard parameters.
  • HPV challenge during EVLP serves as a sensitive index of pulmonary vascular reactivity and donor lung quality.
  • Assessing HPV response during EVLP can provide a more nuanced evaluation of lung viability for transplantation.