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Topical 1% propranolol ointment with occlusion in treatment of pyogenic granulomas: An open-label study in 22

Iria Neri1, Carlotta Baraldi1, Riccardo Balestri1

  • 1Section of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Saint Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Pediatric Dermatology
|December 22, 2017
PubMed

Insights

Topical propranolol ointment effectively treats pediatric pyogenic granuloma (PG), a common skin condition. Most cases resolved without side effects, suggesting a promising alternative to destructive therapies.

Area of Science:

  • Dermatology
  • Pediatrics
  • Vascular Neoplasms

Background:

  • Pyogenic granuloma (PG) is a frequent benign vascular tumor affecting skin and mucous membranes, primarily in children and adolescents.
  • Current treatments for PG involve destructive methods, carrying risks of pain, scarring, and pigmentation changes.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical propranolol 1% ointment in treating pediatric cutaneous pyogenic granuloma.

Main Methods:

  • A prospective, single-arm, open-label study was conducted.
  • Children diagnosed with cutaneous PG received a compounded 1% propranolol ointment formulation.
  • Treatment involved daily application with occlusion.

Main Results:

  • Topical propranolol demonstrated significant efficacy, with 59.0% of patients achieving complete regression of PG.
  • An additional 18.2% of patients showed stable disease, while 22.7% did not respond to treatment.
  • No adverse side effects, including skin irritation, allergy, or bleeding, were reported during the study.

Conclusions:

  • Topical propranolol ointment 1% with occlusion is an effective and safe treatment option for pediatric pyogenic granuloma.
  • Early intervention with topical propranolol appears to correlate with improved treatment outcomes.
Abstract

Keywords:
benignneoplasmstherapytopical

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