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Carbapenem Resistance: A Review

Francis S Codjoe1,2, Eric S Donkor3

  • 1Department of Medical Laboratory Sciences (Microbiology Division), School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Korle Bu KB 143 Accra, Ghana. fscodjoe@chs.edu.gh.

Medical Sciences (Basel, Switzerland)
|December 22, 2017
PubMed

Insights

Carbapenem resistance is a global health threat, primarily affecting Gram-negative bacteria. This review details carbapenem resistance mechanisms and worldwide distribution, highlighting data gaps in regions like sub-Saharan Africa.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Carbapenem resistance poses a significant global public health challenge.
  • It is prevalent in Gram-negative pathogens, including Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
  • Resistance can be intrinsic or acquired through transferable carbapenemase-encoding genes.

Purpose of the Study:

  • To provide an in-depth review of carbapenem resistance.
  • To offer up-to-date information on carbapenem resistance mechanisms and epidemiology.
  • To highlight geographical variations in carbapenem resistance, noting under-documented regions.

Main Methods:

  • Literature review of carbapenem resistance.
  • Synthesis of current data on resistance mechanisms.
  • Analysis of global distribution patterns of carbapenemase-encoding genes.

Main Results:

  • Carbapenem resistance is widespread globally, particularly in Europe, Asia, and South America.
  • Gram-negative pathogens are the primary carriers of carbapenem resistance.
  • The prevalence and documentation of carbapenem resistance in sub-Saharan Africa require further investigation.

Conclusions:

  • Carbapenem resistance is a critical and evolving public health issue.
  • Understanding the epidemiology and mechanisms of carbapenem resistance is crucial for effective control.
  • Further research is needed to fully characterize carbapenem resistance in under-documented geographical areas.
Keywords:
Gram negative bacilliantibiotic resistancecarbapenemasescarbapenems

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