Red nodule on the face with "spontaneous" regression

Area of Science:

• Dermatology
• Pathology

Background:

• Pseudolymphomatous folliculitis is a rare cutaneous pseudolymphoma.
• It is often misdiagnosed due to its presentation.
• Understanding its histopathological features is crucial for diagnosis.

Observation:

• A 32-year-old man presented with a two-month history of an asymptomatic solitary nodule on his left cheek.
• Histopathology revealed a dense dermal lymphocytic infiltrate with histiocytes and dendritic cells surrounding hypertrophic hair follicles.

Findings:

• Pseudolymphomatous folliculitis typically affects individuals in their fourth decade.
• It presents as a solitary, asymptomatic, rapidly growing, dome-shaped facial nodule.
• The condition has a benign clinical course.

Implications:

• Lesions usually resolve with surgical excision or spontaneous regression after biopsy.
• While no progression to lymphoma has been reported, patient follow-up is recommended.
• Accurate diagnosis prevents unnecessary aggressive treatment.