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C-reactive protein/albumin ratio is associated with lung function among children/adolescents with cystic fibrosis: a

Julia Carvalho Ventura1, Daniela Barbieri Hauschild1, Emília Addison Machado Moreira2

  • 1MSc. Doctoral Student, Postgraduate Program on Nutrition, Universidade Federal de Santa Catarina (UFSC), Florianópolis (SC), Brazil.

Sao Paulo Medical Journal = Revista Paulista De Medicina
|December 22, 2017
PubMed

Insights

In cystic fibrosis patients, a high C-reactive protein/albumin ratio at baseline predicted reduced lung function after three years. This inflammatory marker is a key indicator for monitoring disease progression in pediatric cystic fibrosis.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Immunology
  • Biomarkers in Chronic Disease

Background:

  • Cystic fibrosis (CF) is characterized by chronic lung infections, inflammation, and poor nutritional status, impacting patient prognosis.
  • These factors are critical indicators of morbidity in individuals with CF.
  • Understanding the interplay between inflammation and clinical outcomes is crucial for managing CF.

Purpose of the Study:

  • To investigate the association between specific inflammatory markers and lung function, nutritional status, and overall morbidity in children and adolescents with CF.
  • To identify predictive inflammatory markers for long-term clinical outcomes in pediatric CF patients.

Main Methods:

  • A prospective, three-year longitudinal study was conducted in an outpatient CF clinic.
  • Nutritional status, inflammatory markers (TNF-α, IL-1β, MPO, CRP, CRP/albumin ratio), lung function (FEV1), and morbidity (hospitalizations, P. aeruginosa infections) were assessed in children/adolescents aged 1-15 years.
  • Statistical analysis used odds ratios and 95% confidence intervals to determine the effect of baseline inflammatory markers on clinical outcomes.

Main Results:

  • Thirty-eight children/adolescents with CF were evaluated.
  • A high baseline C-reactive protein/albumin ratio was significantly associated with a 18-fold increased odds of having forced expiratory volume in the first second (FEV1) ≤ 70% after three years (P = 0.018).
  • Other inflammatory markers assessed did not show a significant association with the studied clinical outcomes.

Conclusions:

  • The C-reactive protein/albumin ratio is a significant predictor of reduced lung function in pediatric patients with cystic fibrosis over a three-year period.
  • This inflammatory marker can serve as a valuable tool for assessing long-term prognosis and guiding management strategies in pediatric CF care.
Abstract

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