Related Experiment Video
Updated: Feb 16, 2026
Author Spotlight: Leptospira DNA Detection in Water for Environmental Analysis and Disease Surveillance
Published on: June 14, 2024
IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis
Maria Ines Rosa1, Maria Fernandes Dos Reis2, Carla Simon3
1Programa de Pós-Graduação em Saúde Coletiva, Universidade do Extremo Sul Catarinense (UNESC). Av. Universitária 1105, Bairro Universitário. 88806-000 Criciúma SC Brasil. mir@unesc.net.
Abstract:
A systematic review with meta-analysis was performed to estimate the accuracy of IgM ELISA for Leptospirosis diagnosis. A search of Medline, Lilacs, Embase, Cochrane Central Register of Controlled Trials and Grey literature (Google Scholar and British Library) was conducted. The medical subject headings (MeSHs) and the words "leptospirosis", "human leptospirosis" and "IgM ELISA" were used. Fifty-two studies were analyzed, which included 10,775 samples. The pooled sensitivity of all the studies was 86% (CI 95%, 85%-87%) and specificity was 90% (CI 95%, 89%-91%). In studies of the acute phase, the sensitivity and specificity were 84% (CI 95%, 82%-85%) and 91% (CI 95%, 90%-91%), respectively. In conclusion, IgM ELISA is sensitive for use as an initial screen for leptospiral infections.
