Related Experiment Video
Updated: Sep 5, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
Epidemiology of Zika Virus Infection
Susan L Hills1, Marc Fischer1, Lyle R Petersen1
1Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado.
Abstract:
Long known to be endemic in Africa and Southeast Asia and a rare cause of acute febrile illness, Zika virus (ZIKAV) arose from obscurity when an Asian genotype ZIKAV caused an outbreak of mild febrile illness in 2007 in Yap State, Federated States of Micronesia. Subsequent viral spread in the Pacific led to a large outbreak in French Polynesia commencing in 2013. After its recognition in the Americas through March 2017, the Pan American Health Organization has received reports of >750000 suspected and laboratory-confirmed cases of autochthonous ZIKAV transmission. Outbreaks in most countries in the Americas peaked in early to mid-2016. Increased surveillance in several Southeast Asian counties has led to increased case recognition, including an outbreak in Singapore, and the first reports of birth defects linked to ZIKAV in the region. As of April 2017, the World Health Organization reported 84 countries or territories with current or previous ZIKAV transmission.
Insights
Zika virus (ZIKAV) emerged from obscurity, causing widespread outbreaks in the Pacific, Americas, and Asia. This global spread highlights the urgent need for continued surveillance and understanding of ZIKAV transmission and its associated health risks.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Zika virus (ZIKAV) was historically endemic in Africa and Southeast Asia.
- An Asian genotype ZIKAV outbreak in 2007 marked its emergence from obscurity.
- Global spread led to significant outbreaks in the Pacific and Americas.
Purpose of the Study:
- To document the emergence and global spread of Zika virus.
- To highlight the scale of ZIKAV transmission and associated health concerns.
- To underscore the importance of enhanced surveillance for emerging infectious diseases.
Main Methods:
- Review of reported ZIKAV cases and outbreaks.
- Analysis of ZIKAV spread across different geographical regions.
- Monitoring of public health organization reports and surveillance data.
Main Results:
- ZIKAV caused a major outbreak in the Pacific starting in 2013.
- Over 750,000 suspected and confirmed cases reported in the Americas by March 2017.
- Increased case recognition and birth defect reports in Southeast Asia, with 84 countries reporting ZIKAV transmission by April 2017.
Conclusions:
- Zika virus (ZIKAV) represents a significant global public health threat.
- The virus has demonstrated rapid geographic spread and potential for severe health outcomes.
- Continued international surveillance and research are critical for managing ZIKAV.
More Related Videos
Related Concept Videos
Transmission of Pathogens
Arboviral Encephalitis
Yellow Fever
Malaria
Toxoplasmosis
Encephalitis l: Introduction

