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Related Experiment Videos

Nucleotide sequence of the BALB/c mouse beta-globin complex.

W R Shehee1, D D Loeb, N B Adey

  • 1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27514.

Journal of Molecular Biology
|January 5, 1989
PubMed
Summary

Researchers sequenced mouse chromosome 7, revealing the complete beta-globin gene cluster. This analysis identified numerous long interspersed repetitive sequences (L1) and regions of potential functional significance.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Mammalian Genetics

Background:

  • The beta-globin gene cluster is crucial for hemoglobin production.
  • Understanding the genomic organization of this cluster provides insights into gene regulation and evolution.

Purpose of the Study:

  • To report the complete nucleotide sequence of the mouse beta-globin gene cluster.
  • To identify and characterize repetitive elements and homologous regions within this cluster.

Main Methods:

  • DNA sequencing of 55,856 base-pairs from mouse chromosome 7.
  • Low stringency computer searches for homologous sequences.
  • Dot-plot comparisons with self and human sequences.

Main Results:

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  • The sequence encompasses all seven beta-globin homologous structures.
  • Long interspersed repetitive sequences (L1) constitute approximately 22% of the cluster, with at least 15 elements.
  • Several regions of intergenic homology were detected between mouse and human beta-globin sequences.

    • Conclusions:

    • The mouse beta-globin complex is rich in L1 repeats, exceeding previous predictions.
    • Identified homologous regions warrant further investigation for functional roles in erythroid cells or transgenic models.