A Facile Ion-Doping Strategy To Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Multimodal theranostic systems promise improved cancer treatment efficiency but face technical challenges.
• Developing integrated systems for simultaneous diagnosis and therapy is crucial for advanced cancer care.

Purpose of the Study:

• To develop a novel, easily synthesized, large-scale multimodal theranostic nanoconstruct for enhanced cancer treatment.
• To create a nanoconstruct capable of dual-regulating intracellular oxygen and glutathione, transporting iron ions, and performing thermal and magnetic resonance imaging.

Main Methods:

• Fabrication of Fe-doped polydiaminopyridine nanofusiforms.
• Co-loading of dihydroartemisinin and methylene blue onto the nanoconstruct.
• In vitro and in vivo evaluation of theranostic efficacy, including imaging and therapeutic effects.

Main Results:

• The nanoconstruct demonstrated facile synthesis and large-scale production.
• Dual-regulation of intracellular oxygen and glutathione levels was achieved.
• Effective thermal and magnetic resonance imaging capabilities were confirmed.
• Co-loaded dihydroartemisinin and methylene blue significantly enhanced photochemotherapy, leading to near-complete tumor destruction.

Conclusions:

• The developed Fe-doped polydiaminopyridine nanoconstruct represents a promising multimodal theranostic agent for cancer therapy.
• This approach offers enhanced photochemotherapy efficiency and biodegradability.
• The nanoconstruct provides an attractive strategy for developing advanced multimodal anticancer theranostics.