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Pazopanib-induced Endothelial Injury with Podocyte Changes
Keisuke Maruyama1, Naoki Nakagawa1, Ayana Suzuki1
1Division of Cardiology, Nephrology, Respiratory and Neurology, Department of Internal Medicine, Asahikawa Medical University, Japan.
Internal Medicine (Tokyo, Japan)
|December 23, 2017
Summary
Pazopanib, a cancer drug, can cause nephrotic syndrome. A kidney biopsy revealed specific cellular damage, confirming pazopanib as the cause. Proteinuria resolved after stopping the medication.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Pazopanib is a tyrosine kinase inhibitor used in cancer treatment.
- Proteinuria is a known potential side effect of pazopanib.
- Pathological evidence linking pazopanib to specific kidney damage was previously lacking.
Observation:
- A 31-year-old male patient with rhabdomyosarcoma developed nephrotic syndrome during pazopanib treatment.
- Renal biopsy was performed to investigate the cause of nephrotic syndrome.
- Biopsy findings showed endothelial injury and podocyte changes in the kidney.
Findings:
- The observed pathological changes confirmed pazopanib-induced nephrotic syndrome.
- Discontinuation of pazopanib led to a gradual decrease in proteinuria.
- No specific treatment was required for the resolution of proteinuria.
Implications:
- This case highlights the importance of considering pazopanib as a cause of nephrotic syndrome.
- Renal biopsy is crucial for diagnosing drug-induced kidney injury.
- Clinicians should monitor patients on pazopanib for renal complications and consider drug cessation if nephrotic syndrome develops.
Keywords:
adverse effectnephrotic syndromeonco-nephrologypazopanibproteinuriathrombotic microangiopathyMore Related Videos
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