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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Mechanoreciprocity in cell migration.

Sjoerd van Helvert1, Cornelis Storm2, Peter Friedl3,4,5

  • 1Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Nature Cell Biology
|December 23, 2017
PubMed
Summary
This summary is machine-generated.

Cell migration involves cells sensing and responding to tissue mechanics. This bi-directional interaction, or mechanoreciprocity, drives cell movement and tissue organization.

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Last Updated: Feb 16, 2026

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Analysis of Cell Migration within a Three-dimensional Collagen Matrix
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Area of Science:

  • Biophysics
  • Cell Biology
  • Tissue Engineering

Background:

  • Cell migration is a fundamental biological process.
  • It is influenced by physical and molecular cues within the cellular microenvironment.
  • Understanding cell-tissue interactions is crucial for tissue development and disease.

Purpose of the Study:

  • To explore the concept of mechanoreciprocity in cell migration.
  • To elucidate how cells sense and respond to tissue mechanics.
  • To discuss the implications of these interactions for tissue organization and cell fate.

Main Methods:

  • Review of existing literature on cell migration and mechanobiology.
  • Analysis of bi-directional cell-tissue interactions.
  • Discussion of molecular and physical triggers influencing cell movement.

Main Results:

  • Cell migration is an adaptive process responding to mechanical and molecular signals.
  • Cells induce modifications in the extracellular matrix, such as stiffening and remodeling.
  • Mechanoreciprocity enables cell movement and influences tissue structure and cell fate.

Conclusions:

  • The bi-directional relationship between cells and tissues (mechanoreciprocity) is key to cell migration.
  • This interaction contributes to single-cell and collective movement.
  • Mechanoreciprocity plays a role in tissue organization, structural modifications, and cell fate decisions.