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Medical management of aortic disease in Marfan syndrome

Syed Usman Bin Mahmood1, Camilo A Velasquez1, Mohammad A Zafar1

  • 1Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

Annals of Cardiothoracic Surgery
|December 23, 2017
PubMed

Insights

Marfan syndrome patients require medical management for thoracic aortic aneurysms. Beta-blockers are standard, but angiotensin receptor blockers may be a better alternative for managing aortic disease in Marfan syndrome.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Pharmacology

Background:

  • Marfan syndrome (MFS) is an inherited connective tissue disorder.
  • MFS commonly causes cardiovascular complications, particularly affecting the aorta.
  • Aortic dilatation, dissection, and rupture are life-threatening risks in MFS patients.

Purpose of the Study:

  • To review current evidence on medical management of thoracic aortic aneurysm disease in Marfan syndrome.
  • To compare the efficacy of beta-blockers and angiotensin receptor blockers (ARBs) in MFS patients.

Main Methods:

  • Literature review of current evidence.
  • Analysis of clinical guidelines and research studies on MFS medical management.

Main Results:

  • Beta-blockers are the established standard of care for MFS-related aortic disease.
  • Angiotensin receptor blockers (ARBs) show comparable or superior efficacy to beta-blockers.
  • Evidence supports ARBs as a potential alternative or adjunct therapy.

Conclusions:

  • Medical management is crucial for preventing aortic complications in Marfan syndrome.
  • ARBs represent a promising therapeutic option for MFS patients with thoracic aortic aneurysm disease.
  • Further research may refine treatment guidelines for optimal patient outcomes.
Keywords:
Marfan syndrome (MFS)Thoracic aortic aneurysmaortic dissectionmedical management

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