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Endovascular therapy in Marfan syndrome: PRO

Bruce Tjaden1, Ali Azizzadeh2

  • 1Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.

Annals of Cardiothoracic Surgery
|December 23, 2017
PubMed

Insights

Endovascular treatment for Marfan syndrome (MFS) carries risks but is appropriate in specific cases like rupture or reintervention. Careful patient selection is crucial for managing aortic pathologies in MFS patients.

Area of Science:

  • Cardiovascular Surgery
  • Genetics
  • Vascular Medicine

Background:

  • Marfan syndrome (MFS) is an inherited connective tissue disorder.
  • MFS is characterized by arterial fragility and aortic pathologies.
  • Endovascular treatment for MFS patients is a debated topic.

Purpose of the Study:

  • To review the literature on endovascular treatment in Marfan syndrome.
  • To present an institutional perspective on managing MFS aortic pathologies.
  • To evaluate the appropriateness of endovascular interventions in specific MFS scenarios.

Main Methods:

  • Literature review of endovascular interventions in Marfan syndrome.
  • Analysis of institutional experience and case series.
  • Evaluation of immediate and midterm outcomes, including complications.

Main Results:

  • Endovascular interventions in MFS can have low immediate morbidity and mortality.
  • Midterm follow-up reveals a significant number of complications.
  • Specific situations like rupture, reintervention, and graft landing zones are suitable for endovascular approaches.

Conclusions:

  • Endovascular treatment for Marfan syndrome is complex and requires careful consideration.
  • While immediate outcomes can be favorable, midterm complications are a concern.
  • Selective application of endovascular techniques is appropriate in select MFS patients with aortic disease.
Keywords:
EndovascularMarfanaortaconnective tissue

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