[Research progress in the modulating effect of high-density lipoprotein on neutrophil function]

Area of Science:

• Immunology and Molecular Biology
• Biochemistry
• Clinical Medicine

Background:

• High-density lipoprotein (HDL) research traditionally focused on cardiovascular disease.
• Emerging evidence highlights HDL's significant role in diabetes, metabolic syndrome, kidney disease, and inflammatory/autoimmune/infectious diseases.
• Neutrophils are key inflammatory cells implicated in numerous pathologies.

Purpose of the Study:

• To elucidate the role of HDL in modulating neutrophil function.
• To explore the mechanisms by which HDL regulates neutrophil activity.
• To investigate the clinical relevance of HDL-neutrophil interactions in various diseases.

Main Methods:

• Review of existing literature on HDL and neutrophil function.
• Analysis of experimental studies demonstrating HDL's inhibitory effects on neutrophil activation.
• Examination of clinical data correlating HDL levels with inflammatory markers and disease severity.

Main Results:

• HDL inhibits activated neutrophil functions, including cytokine production, deformation, adhesion, transmigration, and pathogen elimination.
• Serum HDL levels show a negative correlation with the neutrophil-to-lymphocyte ratio in healthy males with low HDL.
• HDL levels are associated with disease severity in conditions like severe acute pancreatitis.

Conclusions:

• HDL exerts significant regulatory effects on neutrophil function.
• Understanding HDL's mechanisms in neutrophil regulation is crucial for developing therapeutic strategies against neutrophil-driven diseases.
• HDL's broader role in inflammation warrants further investigation across diverse medical fields.