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Updated: Feb 16, 2026
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
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Correlation between Survivin expression and laryngeal carcinoma: A meta-analysis
Juan Geng1, Yan-Rong Lei2, Sheng-Guang Pei3
1Department of Medical Records and Statistics, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Summary
Survivin expression is significantly different in laryngeal cancer tissues compared to normal tissues. High Survivin expression correlates with advanced stage, poor differentiation, and lymph node metastasis, indicating a poor prognosis for laryngeal cancer patients.
Area of Science:
- Oncology
- Molecular Biology
Background:
- Laryngeal cancer poses a significant health challenge globally.
- Understanding molecular markers is crucial for improving diagnosis and treatment.
- Survivin is a protein implicated in cell division and apoptosis.
Purpose of the Study:
- To meta-analyze the association between Survivin expression and clinicopathological features in laryngeal carcinoma.
- To provide evidence for evidence-based medicine in laryngeal cancer treatment and prognosis in China.
Main Methods:
- Electronic retrieval of case-control studies from China.
- Inclusion of 25 studies with 1333 laryngeal cancer cases and 528 controls.
- Meta-analysis of Survivin expression and its correlation with clinical and pathological features.
Main Results:
- Survivin expression was significantly higher in laryngeal cancer tissues than in controls (OR=18.34).
- High Survivin expression was associated with lymph node metastasis (OR=0.25), advanced clinical stage (Stage III-IV, OR=0.24), and high differentiation (OR=0.33).
- Significant differences in Survivin expression were observed across different T stages (OR=0.35).
Conclusions:
- Survivin plays a critical role in the occurrence and development of laryngeal carcinoma.
- Elevated Survivin expression is linked to poorer prognosis in laryngeal cancer patients.
- Further research into Survivin as a therapeutic target is warranted.
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