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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
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Challenge in particle delivery to cells in a microfluidic device
Hajar Moghadas1, Mohammad Said Saidi2, Navid Kashaninejad1
1School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Drug Delivery and Translational Research
|December 23, 2017
Summary
Microfluidic systems show promise for drug delivery. Simulations reveal liquid flow effectively delivers micro/nanoparticles to cell culture sections, unlike air flow for larger particles.
Area of Science:
- Biotechnology
- Microfluidics
- Nanotechnology
Background:
- Microfluidic systems are crucial for advanced drug delivery systems.
- Cellular functions are sensitive to hydrostatic and hydrodynamic forces in microchannels.
Purpose of the Study:
- To simulate particle transport and deposition in microfluidic channels for drug delivery.
- To evaluate the impact of flow conditions and particle size on delivery efficiency.
Main Methods:
- Numerical simulations of air and liquid flow, particle transport, and deposition.
- Analysis of shear stress on cells within microchannels.
- Experimental validation of particle delivery using microfluidic systems.
Main Results:
- Liquid flow effectively delivers both small and large microparticles to the cell culture section (CCS).
- Air flow can deliver nanoparticles (100-200 nm) to the CCS at increased flow rates.
- Larger microparticles (micrometer range) are not efficiently delivered via air flow.
Conclusions:
- Liquid carriers are recommended for transporting larger particles in microfluidic drug delivery.
- Microfluidic simulations significantly reduce experimental costs and time for optimizing drug delivery strategies.
- Understanding flow dynamics is key to efficient micro/nanocarrier-based drug delivery.
