[Effect of Panax notoginseng preparations on platelet function]

Area of Science:

• Pharmacology and Traditional Medicine
• Cardiovascular Research
• Evidence-Based Medicine

Background:

• Platelet aggregation plays a critical role in thrombotic events.
• Panax notoginseng preparations (PNPs) are widely used in traditional medicine for cardiovascular health.
• The antiplatelet effects of PNPs require systematic evaluation.

Purpose of the Study:

• To systematically evaluate the efficacy of Panax notoginseng preparations (PNPs) on platelet function.
• To assess the impact of PNPs, alone and in combination with other agents, on platelet aggregation markers.
• To evaluate the safety profile of PNPs concerning hemorrhagic adverse events.

Main Methods:

• A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted.
• Searched six major literature databases for relevant RCTs.
• Assessed risk of bias using the Cochrane handbook and analyzed data with RevMan 5.3 software.

Main Results:

• PNPs significantly reduced the MPAR level compared to placebo and non-antiplatelet agents.
• Combination therapy with PNPs and non-antiplatelet agents reduced MPAR and TXB2.
• PNPs combined with anti-platelet agents showed enhanced effects on MPAR and TXB2, without increasing adverse events.

Conclusions:

• Panax notoginseng preparations demonstrate significant potential in reducing platelet aggregation markers, specifically MPAR and TXB2.
• Combining PNPs with anti-platelet or non-antiplatelet agents can improve therapeutic efficacy.
• High clinical heterogeneity and methodological limitations necessitate further rigorous clinical trials to strengthen the evidence base.