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Updated: Feb 16, 2026
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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
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From the intestinal flora to the microbiome.
Juan José Sebastián Domingo1, Clara Sánchez Sánchez2
1Digestivo, Hospital Royo Villanova, España.
Revista Espanola De Enfermedades Digestivas
|December 23, 2017
Summary
This review defines key microbiota terms and discusses its functions and role in gastrointestinal diseases. Fecal microbiota transplantation shows promise for treating digestive illnesses.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- The human microbiota, comprising trillions of microorganisms, plays a crucial role in health and disease.
- Understanding the complex interactions within the microbiota is essential for advancing medical science.
Observation:
- This article reviews the historical context and defines core concepts such as microbiota, microbiome, metagenome, pathobiont, dysbiosis, holobiont, phylotype, and enterotype.
- Current knowledge on the metabolic, nutritional, and immunomodulatory functions of the microbiota is presented.
Findings:
- The pathogenesis of several gastrointestinal diseases, including inflammatory bowel disease, irritable bowel syndrome, and celiac disease, is linked to the intestinal microbiota.
- Fecal microbiota transplantation (FMT) is emerging as a promising therapeutic strategy for specific digestive disorders.
Implications:
- A comprehensive understanding of the microbiota is vital for diagnosing and treating a range of gastrointestinal and immune-related conditions.
- Further research into microbiota modulation, including FMT, holds significant potential for novel therapeutic interventions in digestive health.
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