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Imaging of osteoarthritis-recent research developments and future perspective
Daichi Hayashi1,2, Frank W Roemer1,3, Ali Guermazi1
11 Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine , Boston, MA , USA.
The British Journal of Radiology
|December 23, 2017
Summary
Recent advancements in osteoarthritis (OA) imaging research focus on MRI, particularly compositional techniques, for early detection and drug development. Radiography remains key for clinical trials, while ultrasound and PET/MRI show emerging potential.
Area of Science:
- Orthopedics
- Radiology
- Biomedical Engineering
Background:
- Imaging is crucial for osteoarthritis (OA) research, including clinical trials and epidemiological studies.
- Current research focuses on advancements in OA imaging, primarily from literature published between 2014-2017.
- Understanding OA progression and developing disease-modifying drugs are key research objectives.
Purpose of the Study:
- To review recent developments in osteoarthritis imaging within the research domain.
- To highlight advanced magnetic resonance imaging (MRI) techniques beyond routine clinical practice.
- To discuss the roles of radiography, ultrasound, and nuclear medicine in OA research.
Main Methods:
- Narrative review of scientific literature published within the past three years (2014-2017).
- Primary focus on magnetic resonance imaging (MRI), including advanced compositional techniques.
- Secondary discussion of radiography, ultrasound, and nuclear medicine (radiotracer) imaging.
Main Results:
- Compositional MRI techniques are increasingly important for assessing "premorphologic" biochemical changes in joint tissues.
- Radiography remains the standard for OA clinical trial inclusion/exclusion criteria and outcome measures, despite limitations.
- Ultrasound is a valuable adjunct for hand OA evaluation; hybrid PET/MRI shows future potential.
Conclusions:
- Advanced MRI, especially compositional techniques, shows promise for predicting OA structural and clinical outcomes.
- Continued research into novel imaging modalities is essential for advancing OA understanding and treatment.
- Integrated imaging approaches may offer comprehensive insights into OA pathogenesis and progression.
