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Evolving concepts in dilated cardiomyopathy

Marco Merlo1, Antonio Cannatà1, Marco Gobbo1

  • 1Cardiovascular Department 'Ospedali Riuniti' and University of Trieste, Trieste, Italy.

European Journal of Heart Failure
|December 23, 2017
PubMed

Insights

Dilated cardiomyopathy (DCM) is a genetic heart failure often affecting young people. Advances improve prognosis, but key management questions regarding diagnosis, genotype-phenotype links, and arrhythmia risk remain.

Area of Science:

  • Cardiology
  • Genetics
  • Heart Failure

Background:

  • Dilated cardiomyopathy (DCM) is a primary cause of systolic heart failure, often with a genetic basis.
  • It typically affects younger individuals with minimal comorbidities.
  • Prognosis has improved due to better etiological understanding and integrated care.

Purpose of the Study:

  • To provide a comprehensive review of current clinical management of DCM.
  • To address unresolved issues in DCM diagnosis and risk stratification.
  • To offer practical recommendations for managing DCM.

Main Methods:

  • Literature review of recent advancements in DCM.
  • Analysis of emerging issues in clinical management.
  • Synthesis of evidence for practical recommendations.

Main Results:

  • DCM management has advanced through etiological characterization and systematic screening.
  • Key challenges persist in cardiac magnetic resonance utility, genotype-phenotype correlations, and arrhythmia risk assessment.
  • The dynamic nature of DCM necessitates ongoing treatment optimization.

Conclusions:

  • Despite improved outcomes, critical management aspects of DCM require further investigation.
  • Addressing unresolved issues like advanced imaging and genetic insights is crucial.
  • Continuous optimization of evidence-based treatments is essential for DCM patients.

Keywords:
Dilated cardiomyopathyGeneticsHeart failureLeft ventricular reverse remodellingRisk stratificationSudden cardiac death

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