Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

25.3K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
25.3K
RNA Splicing01:32

RNA Splicing

60.8K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.8K
RNA Editing02:23

RNA Editing

9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K
Translation01:31

Translation

18.2K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
18.2K
Translation01:31

Translation

157.5K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
157.5K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

15
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
15

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Steroidal compounds from Daedaleopsis confragosa suppress breast cancer via Src inhibition.

Food chemistry·2026
Same author

Loss of p300/CBP-associated factor aggravates cardiac remodeling via regulation of CAMKK2 acetylation.

Experimental & molecular medicine·2026
Same author

Ferroptosis-mediated anticancer activity of endoperoxide-containing steroids derived from <i>Daedaleopsis confragosa</i> via targeting NOS2.

Animal cells and systems·2025
Same author

NK cell immunotherapy administered at the time of HIV recrudescence is associated with viral control.

bioRxiv : the preprint server for biology·2025
Same author

The role of Ephexin1 in translation and mTOR-targeted cancer therapy.

Experimental & molecular medicine·2025
Same author

Exploring transcriptome plasticity at the intersection of cell signaling, metabolism and computational biology.

Experimental & molecular medicine·2025

Related Experiment Video

Updated: Feb 16, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.4K

Alternative Polyadenylation in Human Diseases.

Jae Woong Chang1, Hsin Sung Yeh1, Jeongsik Yong2

  • 1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities College of Biological Sciences, Minneapolis, MN, USA.

Endocrinology and Metabolism (Seoul, Korea)
|December 23, 2017
PubMed
Summary

Alternative polyadenylation (APA) regulates gene expression by varying messenger RNA (mRNA) 3' untranslated region lengths. This process impacts cell growth, differentiation, and disease, involving complex molecular mechanisms.

Keywords:
3' Untranslated regionsPolyadenylationRNA 3' end processingTOR serine-threonine kinases

More Related Videos

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.5K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.4K

Related Experiment Videos

Last Updated: Feb 16, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.4K
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.5K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Gene Regulation

Background:

  • Alternative polyadenylation (APA) generates variable messenger RNA (mRNA) 3'-untranslated region lengths.
  • APA is a widespread mechanism in eukaryotes controlling gene expression.
  • APA is crucial for cellular processes like growth, proliferation, and differentiation.

Purpose of the Study:

  • To review the diverse functions of APA in physiological conditions.
  • To explore APA's role in various disease models.
  • To discuss the molecular mechanisms regulating APA.

Main Methods:

  • Literature review of studies on alternative polyadenylation.
  • Analysis of APA's involvement in cellular metabolism and protein diversity.
  • Examination of molecular mechanisms including RNA-binding proteins and signaling pathways.

Main Results:

  • APA influences cellular metabolism, mRNA processing, and protein diversity.
  • Dysregulation of APA is linked to various disease models.
  • APA regulation involves mRNA processing factors and RNA-binding proteins.

Conclusions:

  • Alternative polyadenylation is a fundamental mechanism for gene expression control.
  • Understanding APA mechanisms is vital for comprehending cellular function and disease.
  • Further research into APA regulation can reveal therapeutic targets.