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Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling

Yoon Sin Oh1, Hee-Sook Jun2,3,4

  • 1Department of Food and Nutrition, Eulji University, Seongnam 13135, Korea. ysoh@eulji.ac.kr.

International Journal of Molecular Sciences
|December 23, 2017
PubMed

Insights

Glucagon-like peptide-1 (GLP-1) protects against oxidative stress by activating the Nrf2 pathway. This review explores GLP-1's role in cellular protection and its therapeutic potential for diseases linked to oxidative damage.

Area of Science:

  • Cellular Biology
  • Endocrinology
  • Molecular Medicine

Background:

  • Oxidative cellular damage from free radicals contributes to diseases like cancer, diabetes, and neurodegeneration, and aging.
  • The nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein1 (Keap1) pathway regulates cellular defense against oxidative and inflammatory stresses.
  • Glucagon-like peptide-1 (GLP-1) is an incretin hormone with established roles in glucose control and emerging functions in various organs, including neuroprotective and cardioprotective effects.

Purpose of the Study:

  • To review the current understanding of Glucagon-like peptide-1 (GLP-1) in mitigating oxidative damage.
  • To elucidate the mechanisms by which GLP-1 activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.
  • To highlight the therapeutic implications of GLP-1's antioxidative properties in chronic diseases.

Main Methods:

  • Literature review of studies investigating GLP-1, oxidative stress, and the Nrf2 pathway.
  • Synthesis of findings on GLP-1's antioxidative effects in various cellular and animal models.
  • Analysis of research on GLP-1 receptor agonists and their impact on Nrf2 activation.

Main Results:

  • GLP-1 demonstrates significant protective effects against oxidative stress-induced cellular damage across multiple tissues.
  • Evidence suggests GLP-1 directly or indirectly activates the Nrf2 pathway, enhancing the expression of antioxidant enzymes.
  • GLP-1 receptor agonists show promise in managing chronic diseases characterized by oxidative stress, such as diabetes and cardiovascular conditions.

Conclusions:

  • GLP-1 plays a crucial role in cellular defense against oxidative stress, partly through the activation of the Nrf2 pathway.
  • The antioxidative and Nrf2-activating properties of GLP-1 offer a potential therapeutic strategy for a range of oxidative stress-related diseases.
  • Further research into GLP-1 signaling may uncover novel therapeutic targets for preventing and treating oxidative damage.
Keywords:
Nrf2 signalingdiabetesglucagon-like peptide-1oxidative stressreactive oxygen species

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